Physical and Chemical Properties

The appearance is colorless crystalline powder, with a melting point of 57.6 – 60.3℃; vapor pressure: 0.017 mPa at 20℃, 0.37 mPa at 25℃; KowLog P = 3.72 (at pH 5.7, 25℃); solubility: 73 mg/L in water (at 25℃); in organic solvents (g/L, at 25℃): 730 in ethanol, 770 in acetone, 610 in toluene, 24 in n-hexane, 400 in n-octanol; stability: stable in water, remains stable even at 350℃, does not decompose. 10% emulsified oil of penconazole appears as a light yellow transparent liquid; emulsion stability is qualified; flash point is approximately 55℃; stable in cold, hot storage and at room temperature storage.

Toxicity

The acute oral LD50 of penconazole pure drug in rats is 2125 mg/kg, the acute dermal LD50 is > 3000 mg/kg, and the acute inhalation LC50 (4h) is > 4000 mg/m³. It has no irritation to the eyes and skin of rabbits; the skin of guinea pigs is not sensitizing. The maximum no-effect dose for the subchronic toxicity test of male rats fed for 3 months is 300 ppm; the maximum no-effect dose for the chronic feeding toxicity test of rats for 2 years is 3.8 mg/kg·d. No teratogenic, mutagenic or carcinogenic effects were observed in the test animals. The 10% emulsified solution of penconazole has the same acute oral and acute dermal LD50 > 2000 mg/kg and acute inhalation LC50 (4h) > 4000 mg/m³. It has no irritation to the eyes and skin of rabbits; the skin of guinea pigs is not sensitizing. Penconazole pure drug and 10% emulsified solution are both low-toxicity fungicides.